APOE anticorps

N° du produit ABIN1105420

Détail du produit anti-APOE anticorps

Antigène: APOE (Apolipoprotein E (APOE))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOE est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificité: The antibody reacts with Very Low Density Lipoproteins (VLDL) of Human plasma. It is specific for Human Apo-E. No crossreactions with other Human plasma proteins were detected. This antibody reacts as well with LDL as with VLDL. This antibody recognizes all alleles of Apo-E. In combination with other mabs for detection of VLDL in plasma, and for the specific detection of Apo-E. The antibody is also useful for detection of Apo-E in tissue sections.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium sulfate precipitation + DEAE-cellulose chromatography, gradient elution

Clone: 3D12

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Restore with 1 mL sterile water and add preservative if preferred.

Concentration: 0.5 mg/mL (prior to lyophilization)

Buffer: PBS, None

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur APOE

Antigène: APOE (Apolipoprotein E (APOE))

Autre désignation: Apolipoprotein E (Apo E) (APOE Produits)

Synonymes: anticorps ad2, anticorps apoprotein, anticorps im:7036787, anticorps wu:fb69a05, anticorps zgc:110064, anticorps apoe, anticorps AI255918, anticorps AD2, anticorps LDLCQ5, anticorps LPG, anticorps APOEA, anticorps Apo-E, anticorps apolipoprotein E, anticorps apolipoprotein Ea, anticorps apoe, anticorps apoea, anticorps Apoe, anticorps APOE

Sujet: Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.Synonyms: Apo-E, ApoE

ID gène: 348

NCBI Accession: NP_000032

UniProt: P02649

Pathways: Regulation of Cell Size, Lipid Metabolism