CD38 anticorps

N° du produit ABIN1106330

Détail du produit anti-CD38 anticorps

Antigène: CD38

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD38 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: Clone T16 produces mouse IgG1 immunoglobulins reactive with a 45 kDa antigen on lymphocytes [3]. CD38, clone T16, is widely used in flow cytometry to study T cell activation, B cell differentiation and in monitoring immunodeficiency diseases. CD38 is also reactive with multiple myelomas, most cases of ALL (both T and B lineage) and some cases of AML. In immunohistochemistry CD38, clone T16, reacts strongly with plasma cells and cortical thymocytes, less strongly with germinal center B cells. In clinical research CD38 is mainly used for leukemia and lymphoma typing and detection of plasma cells [4].

Purification: Affinity chromatography

Clone: T16

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Détails sur CD38

Antigène: CD38

Abstract: CD38 Produits

Synonymes: anticorps T10, anticorps Cd38-rs1, anticorps cd38, anticorps ADPRC 1, anticorps cADPr hydrolase 1, anticorps CD38 molecule, anticorps CD38 antigen, anticorps CD38 molecule L homeolog, anticorps ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, anticorps CD38, anticorps Cd38, anticorps cd38.L

Sujet: CD38 is present in low density on human B cells and pre-B cells, subsets of CD4 and CD8 T cells, NK cells and monocytes. CD38 is also found in high density on Ig secreting plasma cells, germinal center B cells, mitogen-activated T cells, and several B and T cells. CD38 is a type II membrane glycoprotein, with the transmembrane sequence near the N-terminus. Antibodies to human CD38 have a wide range of biological effects, incuding the induction of B and T cell proliferation, protection of B cells from apoptosis, inhibition of B lymphopoiesis and enhancement of macrophage APC function [2].Synonyms: ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1, T10, cADPr hydrolase 1

ID gène: 952

NCBI Accession: NP_001766

UniProt: P28907