HMGB1 anticorps

N° du produit ABIN1107584

L’anticorps Souris Monoclonal anti-HMGB1 a été validé pour WB. Il convient pour détecter HMGB1 dans des échantillons de Humain, Souris, Rat et Porc.

Aperçu rapide pour HMGB1 anticorps (ABIN1107584)

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Reactivité: Humain, Souris, Rat, Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HMGB1 est non-conjugé

Application: Western Blotting (WB)

Clone: KS1

Détail du produit anti-HMGB1 anticorps

Specificité: This antibody reacts with human, mouse, rat and porcine HMGB1.

Purification: Protein A agarose

Immunogène: Porcine HMGB1

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur HMGB1

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Autre désignation: HMGB1

Sujet: High mobility group box 1 (HMGB1), named for its rapid migration properties on electrophoretic gels, is a member of the nonhistone chromatin-associated proteins. HMGB1 is translated as a 214 amino acid protein and is extensively modified posttranslationally by glycosylation, acylation, methylation, and phosphorylation. The primary structure is evolutionarily conserved, with 100 % amino acid sequence homology between rat and mouse and 99 % homology between rodent and human. Intracellular HMGB1 has previously been studied for its roles in binding DNA, stabilizing nucleosome formation, as a general transcription factor for nucleolar and mitochondrial RNA polymerases, and as a gene- and tissue-specific transcriptional regulator that can enhance transcription and/or replication. Extracellular HMGB1 has recently been implicated as a late mediator of delayed endotoxin lethality, because murine and human macrophages/monocytes release large amounts of a 29 kDa form of HMGB1 when stimulated by exposure to bacterial endotoxin.Synonyms: Amphoterin, HMG-1, HMG1, HMGB-1, High mobility group protein 1, High mobility group protein B1

Poids moléculaire: 29 kDa

ID gène: 3146

NCBI Accession: NP_002119

UniProt: P09429

Pathways: Signalisation p53, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome