HSPD1 anticorps

N° du produit ABIN1107605

Détail du produit anti-HSPD1 anticorps

Antigène: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Reactivité: Humain, Rat, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HSPD1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody reacts to HSP60.

Purification: Affinity chromatography

Immunogène: Recombinant human heat shock protein 60 (HSP60)

Clone: SJ-60

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 1.2 % sodium acetate or neutral PBS

Concentration: 0,1 mg/mL

Buffer: 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur HSPD1

Antigène: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Autre désignation: HSP60 (HSPD1 Produits)

Synonymes: anticorps CPN60, anticorps GROEL, anticorps HLD4, anticorps HSP-60, anticorps HSP60, anticorps HSP65, anticorps HuCHA60, anticorps SPG13, anticorps chaperonin, anticorps cpn60, anticorps groel, anticorps hld4, anticorps hsp60, anticorps hsp65, anticorps spg13, anticorps 60kDa, anticorps Hsp60, anticorps 12, anticorps BP5, anticorps CG12101, anticorps Cpn60, anticorps Dmel\\CG12101, anticorps Dmhsp60, anticorps G62, anticorps HSP60A, anticorps Hsp60A, anticorps IEF16, anticorps Mmp-P1, anticorps SSP 7506, anticorps d-hsp60, anticorps hsp60A, anticorps l(1)10Ac, anticorps l(1)BP5, anticorps l(1)G8, anticorps l(1)HM21, anticorps l(1)L12, anticorps l(1)dp025, anticorps cb863, anticorps fa04a05, anticorps fb22d10, anticorps fi27b05, anticorps id:ibd2197, anticorps sb:cb144, anticorps wu:fa04a05, anticorps wu:fb22d10, anticorps wu:fi04a12, anticorps wu:fi27b05, anticorps MIF4, anticorps MNA2, anticorps mopA, anticorps groL, anticorps crpA, anticorps Hspd1-30p, anticorps heat shock protein family D (Hsp60) member 1, anticorps heat shock protein family D (Hsp60) member 1 S homeolog, anticorps 60 kDa heat shock protein, mitochondrial, anticorps heat shock protein 1 (chaperonin), anticorps Heat shock protein 60A, anticorps heat shock 60 protein 1, anticorps chaperone ATPase HSP60, anticorps molecular chaperone GroEL, anticorps thermosome subunit, anticorps chaperonin GroEL, anticorps mitochondrial chaperonin, anticorps heat shock protein family D member 1, anticorps HSPD1, anticorps hspd1.S, anticorps hspd1, anticorps LOC100414401, anticorps Hspd1, anticorps Hsp60A, anticorps HSP60, anticorps groEL, anticorps MMP_RS07785, anticorps groEl, anticorps LOC100136430

Sujet: Heat shock 60KD protein (HSP60) is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNFsecretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling.Synonyms: 60 kDa chaperonin, 60 kDa heat shock protein mitochondrial, CPN60, Chaperonin 60, GROEL, GroEL Homolog, HSP-60, HSPD1, Heat shock protein 60, HuCHA60, Mitochondrial matrix protein P1, P60 lymphocyte protein

ID gène: 3329

NCBI Accession: NP_002147

UniProt: P10809

Pathways: Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity