PARP4 anticorps (AA 408-611)

N° du produit ABIN1108588

Détail du produit anti-PARP4 anticorps

Antigène: PARP4 (Poly (ADP-Ribose) Polymerase Family, Member 4 (PARP4))

Épitope: AA 408-611

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PARP4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This Monoclonal antobofdy P193-4 reacts with an internal epitope (amino acids 491-494, HPGE) of the minor vault protein (P193 or VPARP), which is overexpressed in various Human non-P-glycoprotein MDR tumor cell lines, accordingly to an increase in the number of vault particles.

Réactivité croisée (Details): Species reactivity (tested):Human.

Immunogène: E. coli lysate transformed with pET28a(+) expression vector containing amino acids 408-611 of the p193 cDNA.

Clone: P193-4

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg IgG/ml

Buffer: 0.09 % Sodium Azide 9 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PARP4

Antigène: PARP4 (Poly (ADP-Ribose) Polymerase Family, Member 4 (PARP4))

Autre désignation: PARP4 (PARP4 Produits)

Synonymes: anticorps ADPRTL1, anticorps ARTD4, anticorps PARP-4, anticorps PARPL, anticorps PH5P, anticorps VAULT3, anticorps VPARP, anticorps VWA5C, anticorps p193, anticorps Adprtl1, anticorps C030027K23Rik, anticorps E230037B21Rik, anticorps Gm743, anticorps poly(ADP-ribose) polymerase family member 4, anticorps poly (ADP-ribose) polymerase family, member 4, anticorps PARP4, anticorps Parp4

Sujet: PARP-1 is a nuclear protein that is specifically cleaved by caspase-3 and caspase-6, but not by caspase-1, into a signature apoptotic fragment. PARP-2 and PARP-3 interact with PARP-1. PARP-4, also designated vault poly(ADP-ribose) polymerase (VPARP) and ADP-ribotransferase-like 1 (ADPRTL1), associates with the major vault protein (MVP) and telomerase-associated protein 1 (TEP1) to form vaults, barrel-shaped cytoplasmic ribonucleoprotein particles. PARP-4 localizes mainly to the cytoplasm but is also found in the nucleus. The PARP-4 protein is expressed widely, with highest levels observed in the kidney, and is also detected in skeletal muscle, heart, leukocytes, placenta, lung, liver, spleen, and pancreas. PARP-4 contains a PARP (ADPRT)-like catalytic domain, a C-terminal MVP-interacting domain, a domain with two sequences similar to inter-alpha-trypsin inhibitor, and an N-terminal BRCA1 C-terminus (BRCT) domain, which may be involved in protein-protein interactions.Synonyms: 193 kDa vault protein, ADPRTL1, KIAA0177, PARP-4, PARP-related/IalphaI-related H5/proline-rich, PARPL, Poly [ADP-ribose] polymerase 4, VPARP, Vault poly(ADP-ribose) polymerase

ID gène: 143

NCBI Accession: NP_006428

UniProt: Q9UKK3