RRAD anticorps (Internal Region)

N° du produit ABIN1108906

Détail du produit anti-RRAD anticorps

Antigène: RRAD (Ras-Related Associated with Diabetes (RRAD))

Épitope: AA 36-48, Internal Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp RRAD est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody recognizes RRAD (36-48).

Réactivité croisée (Details): Species reactivity (expected):Human, Rat, Canine (Dog), Porcine, Bovine.
Species reactivity (tested):Mouse.

Purification: Affinity Chromatography

Immunogène: Peptide with sequence (C-HRRSMPVDERDLQ) from the internal region of Human RRAD (NP_004156.1). Genename: RRAD Remarks: Reported variants represent identical protein: NP_004156.1, NP_001122322.1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur RRAD

Antigène: RRAD (Ras-Related Associated with Diabetes (RRAD))

Autre désignation: RRAD / RAD (RRAD Produits)

Synonymes: anticorps ZGC:63471, anticorps RRAD, anticorps RAD, anticorps RAD1, anticorps REM3, anticorps Rad, anticorps RRAD, Ras related glycolysis inhibitor and calcium channel regulator, anticorps Ras-related associated with diabetes, anticorps RRAD, anticorps Rrad

Sujet: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Synonyms: GTP-binding protein RAD, RAD1, Ras associated with diabetes

Poids moléculaire: 33.2 kDa (Mouse NP_062636.2 and Human NP_004156.1).

ID gène: 6236

NCBI Accession: NP_001122322