SNAP25 anticorps (C-Term)

N° du produit ABIN1109085

Détail du produit anti-SNAP25 anticorps

Antigène: SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNAP25 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects SNAP25 (C-term). No cross reactivity with other proteins.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, rat

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminal of human SNAP25 .Remarks: The sequence is identical to the related rat and mouse sequence.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur SNAP25

Antigène: SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))

Autre désignation: SNAP25 (SNAP25 Produits)

Synonymes: anticorps RIC-4, anticorps RIC4, anticorps SEC9, anticorps SNAP, anticorps SNAP-25, anticorps bA416N4.2, anticorps dJ1068F16.2, anticorps SNAP-25B, anticorps SNAP-25a, anticorps ric-4, anticorps ric4, anticorps sec9, anticorps snap-25, anticorps Bdr, anticorps sp, anticorps fj55h11, anticorps snap25, anticorps wu:fj55h11, anticorps Snap, anticorps snap25.2, anticorps wu:fj33h05, anticorps synaptosome associated protein 25, anticorps synaptosome associated protein 25kDa S homeolog, anticorps synaptosomal-associated protein, 25kDa, anticorps synaptosomal-associated protein 25, anticorps synaptosome associated protein 25kDa, anticorps synaptosome associated protein 25kDa L homeolog, anticorps zgc:101731, anticorps synaptosomal-associated protein, 25b, anticorps SNAP25, anticorps Snap25, anticorps snap25.S, anticorps snap25, anticorps BACOIKO003_07, anticorps Tsp_10811, anticorps snap25.L, anticorps zgc:101731, anticorps snap25b

Sujet: Synaptosome-associated protein of 25,000 daltons also known as SNAP-25 is a protein which in humans encodes a 25-kD protein of 206 amino acids. It was first investigated as a neuron-specific gene preferentially expressed in mouse hippocampus. The tSNARE (the target-membrane soluble NSFattachment protein receptor, where NSF is N-ethylmaleimide-sensitive fusion protein) synaptosomalassociated protein of 25 kDa (SNAP-25) is expressed in pancreatic B-cells and its cleavage by botulinum neurotoxin E (BoNT/E) abolishes stimulated secretion of insulin. In the nervous system, two SNAP-25 isoforms (a and b) have been described, which are produced by alternative splicing. Nagy et al. (2004) identified mammalian Snap25a and Snap25b as targets of protein kinase A, a key regulator of neurosecretion that primes slowly releasable pools and readily releasable pools of secretory vesicles. SNAP-25 inhibits P/Q-and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP-25 decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses.Synonyms: RIC4, SNAP, SNAP-25, SUP, Super Protein, Synaptosomal-associated 25 kDa protein, Synaptosomal-associated protein 25, ric-4

ID gène: 6616

NCBI Accession: NP_003072

UniProt: P60880

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport