TSHZ3 anticorps (Middle Region)

N° du produit ABIN1109362

Détail du produit anti-TSHZ3 anticorps

Antigène: TSHZ3 (ZNF537) (Zinc Finger Protein 537 (ZNF537))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSHZ3 est non-conjugé

Application: Western Blotting (WB)

Séquence: LNVEVKKEVD KEKAVTDEKP KQKDKPGEEE EKCDISSKYH YLTENDLEES

Réactivité croisée (Details): Species reactivity (expected):Mouse, RatSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogène: The immunogen for anti-ZNF537 antibody: synthetic peptide directed towards the middle region of human ZNF537.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Détails sur TSHZ3

Antigène: TSHZ3 (ZNF537) (Zinc Finger Protein 537 (ZNF537))

Autre désignation: TSHZ3 / ZNF537 (ZNF537 Produits)

Synonymes: anticorps ZNF537, anticorps A630038G13Rik, anticorps Tsh3, anticorps Zfp537, anticorps mKIAA1474, anticorps teashirt3, anticorps TSH3, anticorps teashirt zinc finger homeobox 3, anticorps teashirt zinc finger family member 3, anticorps TSHZ3, anticorps Tshz3

Sujet: TSHZ3 is a transcriptional regulator involved in developmental processes. It function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. TSHZ3 associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) and regulates the development of neurons involved in both respiratory rhythm and airflow control. It promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. TSHZ3 ot ZNF537 is involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes and in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.Synonyms: KIAA1474, TSH3, Teashirt homolog 3, Zinc finger protein 537

ID gène: 57616

NCBI Accession: NP_065907

Pathways: Regulation of Muscle Cell Differentiation