LTBR anticorps (Cysteine-Rich Domain)

N° du produit ABIN1169122

Détail du produit anti-LTBR anticorps

Antigène: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Épitope: AA 31-221, Cysteine-Rich Domain

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp LTBR est non-conjugé

Application: Functional Studies (Func)

Specificité: Recognizes mouse LTbetaR.

Réactivité croisée: Souris

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant mouse LTbetaR (cysteine-rich region) (aa 31-221).

Clone: 3C8

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

The monoclonal antibody to mouse LTbetaR is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappaB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappaB2 pathway. For use as an agonist the MAb to LTbetaR is added to cell cultures at 2μg/ml. For in vivo use, mice are injected intraperitoneally with 50μg of agonistic MAb to LTbetaR in sterile phosphate saline buffer.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-LTBR (ABIN1169122)

Vondenhoff, Greuter, Goverse, Elewaut, Dewint, Ware, Hoorweg, Kraal, Mebius: "LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5439-45, (2009) (PubMed).

Benedict, De Trez, Schneider, Ha, Patterson, Ware: "Specific remodeling of splenic architecture by cytomegalovirus." dans: PLoS pathogens, Vol. 2, Issue 3, pp. e16, (2006) (PubMed).

Banks, Rickert, Benedict, Ma, Ko, Meier, Ha, Schneider, Granger, Turovskaya, Elewaut, Otero, French, Henry, Hamilton, Scheu, Pfeffer, Ware: "A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7217-25, (2005) (PubMed).

Détails sur LTBR

Antigène: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Autre désignation: LTbetaR (LTBR Produits)

Synonymes: anticorps AI256028, anticorps CD18, anticorps LTbetaR, anticorps Ltar, anticorps TNF-R-III, anticorps TNFCR, anticorps TNFR-RP, anticorps TNFR2-RP, anticorps TNFRrp, anticorps Tnfbr, anticorps Tnfrsf3, anticorps D12S370, anticorps LT-BETA-R, anticorps TNFR3, anticorps TNFRSF3, anticorps lymphotoxin beta receptor, anticorps lymphotoxin B receptor, anticorps Ltbr, anticorps LTBR

Sujet: The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

UniProt: P50284

Pathways: Signalisation NF-kappaB