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HMGB1 anticorps

HMGB1 Reactivité: Mammifères WB, IHC, IF, Inhibition, CA Hôte: Souris Monoclonal DPH1-1 unconjugated
N° du produit ABIN1176834
  • Antigène Voir toutes HMGB1 Anticorps
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    Reactivité
    • 160
    • 91
    • 90
    • 14
    • 12
    • 12
    • 10
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    Mammifères
    Hôte
    • 137
    • 32
    • 2
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 127
    • 48
    Monoclonal
    Conjugué
    • 90
    • 17
    • 17
    • 8
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp HMGB1 est non-conjugé
    Application
    • 145
    • 64
    • 48
    • 46
    • 33
    • 30
    • 27
    • 26
    • 21
    • 10
    • 9
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Blocking Antibody (Inhibition), Cellular Assay (CA)
    Immunogène
    17-mer peptide KGKPDAAKKGVVKAEKS
    Clone
    DPH1-1
    Isotype
    IgG1
    Top Product
    Discover our top product HMGB1 Anticorps primaire
  • Indications d'application
    WB: 1 µg/ml antibody in 5% milk TBS-T overnight at 4°C. Migration assay: 0.5/1/2/5 µg/ml of DPH1.1 mAb is added to 30 ng/ml of rHMGB1, according to Palumbo et al. “Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation”.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Conseil sur la manipulation
    DPH1.1 mAb is provided freeze-dried.
    Stock
    -20 °C
  • Han, Yuan, Deng, He, Zhang, Shen, Chen, Qian: "Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release." dans: Aging, Vol. 11, Issue 22, pp. 10252-10265, (2020) (PubMed).

  • Antigène
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    Autre désignation
    High-mobility group protein B1 (HMGB1) (HMGB1 Produits)
    Synonymes
    anticorps HMG1, anticorps HMG3, anticorps SBP-1, anticorps DEF, anticorps HMG-1, anticorps Hmg1, anticorps amphoterin, anticorps p30, anticorps hmgb1, anticorps ik:tdsubc_1a5, anticorps wu:fb23c02, anticorps xx:tdsubc_1a5, anticorps zgc:56110, anticorps zgc:77104, anticorps hmg-1, anticorps hmg3, anticorps sbp-1, anticorps hmg1, anticorps HMGB1, anticorps Ac2-008, anticorps high mobility group box 1, anticorps high-mobility group box 1, anticorps high mobility group box 1a, anticorps high mobility group box 1 L homeolog, anticorps high mobility group protein B1, anticorps HMGB1, anticorps Hmgb1, anticorps hmgb1, anticorps hmgb1a, anticorps hmgb1.L, anticorps LOC100359149
    Sujet
    DPH1.1 mAb recognizes all mammalian HMGB1s, including human, mouse and rat. Does not recognize HMGB2. DPH1.1 mAb can be used for Western blot (WB), immunofluorescence (IHF) and immunohistochemistry (IHC). DPH1.1 mAb blocks HMGB1-elicited cell migration in trans-well migration assays. In vivo, DPH1.1 mAb administered intravenously (220 µg/mouse) blocks recruitment of inflammatory cells to sites of necrosis and infection. The mouse monoclonal IgG1 DPH1.1 was generated by injecting C57BL/6 mice with the 17-mer peptide KGKPDAAKKGVVKAEKS. Hybridomas were produced from splenocytes by standard techniques and tested by ELISA against the immunogen and full-length HMGB1.
    Pathways
    Signalisation p53, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
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