No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Agent conservateur
Azide free
Stock
4 °C
Stockage commentaire
Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
van Vugt, Heijnen, Capel, Park, Ra, Saito, Verbeek, van de Winkel: "FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo." dans: Blood, Vol. 87, Issue 9, pp. 3593-9, (1996) (PubMed).
Dougherty, Selvendran, Murdoch, Palmer, Hogg: "The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1." dans: European journal of immunology, Vol. 17, Issue 10, pp. 1453-9, (1987) (PubMed).
Antigène
FCGR1A
(Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))
anticorps CD64, anticorps CD64A, anticorps FCRI, anticorps IGFR1, anticorps FcgammaRI, anticorps Fcgr1, anticorps Fcgr1b, anticorps AI323638, anticorps AV092959, anticorps IGGHAFC, anticorps FCGR1A, anticorps Fc fragment of IgG receptor Ia, anticorps Fc receptor, IgG, high affinity I, anticorps FCGR1A, anticorps Fcgr1a, anticorps Fcgr1
Sujet
The 10.1 monoclonal antibody specifically binds to CD64, a 75 kDa type I transmembrane glycoprotein that is a high affinity receptor for human IgG (FcgammaRI), especially the IgG1 and IgG3 subclasses. CD64 is expressed on monocytes, macrophages, dendritic cells, granulocytes activated with interferon-gamma and early myeloid lineage cells. CD64 associates with a signaling FcRgamma homodimer to form the functional high affinity FcgammaRI complex. CD64 functions in both innate and adaptive immune responses and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release and superoxide generation. Synonyms: FCGR1, FcRI, Fc-gamma RI, IgG Fc Receptor I, High affinity IgG FcR1