SKG1 anticorps (AA 419-431)

N° du produit ABIN129525

Détail du produit anti-SKG1 anticorps

Antigène: SKG1 (Suppressor of lethality of KEX2 GAS1 double null mutant protein 1 (SKG1))

Épitope: AA 419-431

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Réactivité croisée: Souris, Rat (Rattus)

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: SKG-1 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 419-431 of human SGK -1.

Isotype: IgG

Information d'application

Indications d'application: SKG-1 Antibody antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~49 kDa in size corresponding to SGK-1 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 5.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur SKG1

Antigène: SKG1 (Suppressor of lethality of KEX2 GAS1 double null mutant protein 1 (SKG1))

Autre désignation: SKG-1 (SKG1 Produits)

Synonymes: anticorps YKR099C-A, anticorps Suppressor of lethality of KEX2 GAS1 double null mutant protein 1, anticorps SKG1

Sujet: SGK-1 (also called Serine/threonine-protein kinase Sgk1 and Serum/glucocorticoid-regulated kinase 1) is a protein kinase that plays an important role in cellular stress response.  SGK1 activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. This kinase mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A and phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1. SGK1 is localized to the cytoplasm and upon phosphorylation is translocated to the nucleus.  The kinase is expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung.  Induction occurs upon exposure to glucocorticoids and by excessive extracellular glucose or TGF-beta, in cultured cells.   SGK-1 is regulated by phosphorylation.  Phosphoinositide 3-kinase (PI3-kinase) pathway promotes phosphorylation at Ser-422 which in turn increases the phosphorylation of Thr-256 by PDPK1. The kinase is ubiquitinated by NEDD4L; which promotes proteasomal degradation.
Synonyms: Serum/glucocorticoid-regulated kinase 1, SGK1 antibody, Cellular stress response antibodies, Serine/threonine-protein kinase Sgk1

ID gène: 6446

UniProt: O00141