CBLC anticorps (AA 444-458)

N° du produit ABIN129659

Détail du produit anti-CBLC anticorps

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Épitope: AA 444-458

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBLC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 444-458 of Human Cbl-c.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry, immunoprecipitation and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~52 kDa in size corresponding to Cbl-c by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.42 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur CBLC

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Abstract: CBLC Produits

Synonymes: anticorps CBL-3, anticorps CBL-SL, anticorps RNF57, anticorps Cbl proto-oncogene C, anticorps CBLC, anticorps Cblc

Sujet: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57.  Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.  Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed).  Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.  Cbl-c knock out mice show no obvious phenotype.  Thus, the physiological role of Cbl-c is not known.
Synonyms: Cas Br M (murine) ectropic retroviral transforming sequence c antibody, Casitas B lineage lymphoma c antibody, CBL 3 antibody, CBL SL antibody, RING finger protein 57 antibody, RNF57 antibody, SH3 binding protein CBL C antibody

ID gène: 23624, 125987803

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway