ASAP1 anticorps (pTyr782)

N° du produit ABIN129669

Détail du produit anti-ASAP1 anticorps

Antigène: ASAP1 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1 (ASAP1))

Épitope: AA 777-787, pTyr782

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Poulet, Mouton, Chien, Rat (Rattus), Chimpanzé

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 777-787 of mouse ASAP1 protein.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry, IF microscopy and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 130 kDa in size corresponding to phosphorylated ASAP1 protein by western blotting in the appropriate cell lysate or extract.  Less than 2.5% reactivity is observed against the non-phosphorylated form of the immunizing peptide.  This antibody is phospho specific for pY782 of ASAP1 protein.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.09 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ASAP1 (ABIN129669)

Bender, Stritt, Nurden, van Eeuwijk, Zieger, Kentouche, Schulze, Morbach, Stegner, Heinze, Heinze, Dütting, Gupta, Witke, Falet, Fischer, Hartwig, Nieswandt: "Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect." dans: Nature communications, Vol. 5, pp. 4746, (2015) (PubMed).

Détails sur ASAP1

Antigène: ASAP1 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1 (ASAP1))

Autre désignation: ASAP1 (ASAP1 Produits)

Synonymes: anticorps AV239055, anticorps DEF-1, anticorps Ddef1, anticorps PAP, anticorps mKIAA1249, anticorps s19, anticorps AMAP1, anticorps CENTB4, anticorps DDEF1, anticorps PAG2, anticorps ZG14P, anticorps ASAP1, anticorps ddef1, anticorps Asap1, anticorps si:ch211-160i2.3, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain1, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 1, anticorps toxic extracellular endopeptidase, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 L homeolog, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a, anticorps Asap1, anticorps ASAP1, anticorps asaP1, anticorps asap1, anticorps asap1.L, anticorps asap1a

Sujet: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. ASAP1 (also known as AMAP1, 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein, PIP2-dependent ARF1 GAP,ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, Development and differentiation-enhancing factor 1, Differentiation-enhancing factor 1, DEF-1) is an Arf-directed GTPase activating protein that is a substrate for the kinases Src and FAK and has been implicated in the regulation of membrane traffic, focal adhesions and invadopodia/podosomes.  Phosphorylation of ASAP1 at tyrosine 782 has been found to affect enzymatic and some biological activities, including the function of invadopodia. ASAP1 is expressed in many tissues but is most abundant in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals. Multiple transcript variants have been reported for this protein.
Synonyms: Development and differentiation enhancing factor 1 antibody, 130 kDa phosphatidylinositol 4 5 biphosphate dependent ARF1 GTPase activating protein antibody, ADP ribosylation factor directed GTPase activating protein 1 antibody, AMAP 1 antibody

ID gène: 13196, 65301464

UniProt: Q9QWY8