CD45RA/B anticorps (PE)

N° du produit ABIN133316

Détail du produit anti-CD45RA/B anticorps (PE)

Antigène: CD45RA/B

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD45RA/B est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: Rat CD45RA/B

Immunogène: Rat purified spleen L-CA . Fusion Partner: NSO/U . Donor: BALB/c spleen

Clone: OX-33

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Concentration: 0.5 µg/10 cells

Stock: 4 °C

Détails sur CD45RA/B

Antigène: CD45RA/B

Autre désignation: CD45RA/B (CD45RA/B Produits)

Sujet: Rat Leukocyte Common Antigen has been shown to exist in different forms on different lymphoid cell types. Rat L-CA on thymocytes shows one main band at 180 kDa, T cells show 4 bands at 180, 190, 200 and 220 kDa. ABIN133316detects a subfraction of the 240 kDa rat L-CA band found only on B lymphocytes. This monoclonal antibody is of particular use in the investigation of the molecular and antigenic heterogeneity of rat L-CA, especially when used in conjunction with other OX antibodies. Four mouse monoclonal antibodies (MRC OX 1, 28, 29 and 30) react with all molecular forms of L-CA and fall into two sets that are non- competitive in binding to L-CA (MRC OX 1, 28, 29 and 30). The antigenic determinants seen by all these antibodies are lost when L-CA is reduced and alkylated. Three antibodies (MRC OX 22, 31, and 32) react selectively with B cells, T cytotoxic cells and about two thirds of T helper cells. OX 22 and OX 31 compete for binding but are non- competitive with OX 32. All of these antibodies bind to a sub-fraction of the 190, 200 and 220 kDa forms of T cell L-CA but not at all to the 180 kDa form of T cells or thymocytes.