GluR1, GluR2 anticorps (AA 141-240)

N° du produit ABIN1385842

Détail du produit anti-GluR1, GluR2 anticorps

Antigène: GluR1, GluR2 (GRIA1/2) (Glutamate Receptor, Ionotropic, AMPA 1/2 (GRIA1/2))

Épitope: AA 141-240

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GluR1, GluR2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunocytochemistry (ICC)

Specificité: Due to the similarity of this protein to GluR2, there is a chance that this antibody will react with this protein based on homology.

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GluR1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-GluR1, GluR2 (ABIN1385842)

Ku, Li, Gao, Zhang, Yan, Ji, Li, Sang: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." dans: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).

Zhang, Zhang, Li, Xu, Chu, Chen, Chen: "Antioxidant and anti-excitotoxicity effect of Gualou Guizhi decoction on cerebral ischemia/reperfusion injury in rats." dans: Experimental and therapeutic medicine, Vol. 9, Issue 6, pp. 2121-2126, (2015) (PubMed).

Détails sur GluR1, GluR2

Antigène: GluR1, GluR2 (GRIA1/2) (Glutamate Receptor, Ionotropic, AMPA 1/2 (GRIA1/2))

Autre désignation: GluR1, GluR2 (GRIA1/2 Produits)

Sujet:

Synonyms: GLUH1, GLUR1, GLURA, GluA1, HBGR1, Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GRIA1

Background: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

ID gène: 2890

UniProt: P42261