Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) anticorps

Détails pour le produit réf. ABIN1386516, Fournisseur: Connectez-vous pour afficher
Antigène
  • APBA1
  • 6430513E09Rik
  • Lin-10
  • Mint
  • Mint1
  • Urop11
  • X11
  • X11alpha
  • D9S411E
  • LIN10
  • MINT1
  • X11A
  • X11ALPHA
  • amyloid beta precursor protein binding family A member 1
  • amyloid beta (A4) precursor protein-binding, family A, member 1b
  • ketopantoate reductase
  • 2-dehydropantoate 2-reductase
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
  • amyloid beta (A4) precursor protein-binding, family A, member 1
  • amyloid beta (A4) precursor protein binding, family A, member 1
  • APBA1
  • apba1b
  • apbA1
  • apba1
  • Apba1
Reactivité
Humain, Souris, Rat (Rattus)
75
48
41
2
2
1
1
1
1
1
1
1
1
Hôte
Lapin
64
18
Clonalité
Polyclonal
Conjugué
Inconjugué
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
60
47
17
12
7
4
3
2
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human APBA1
Isotype IgG
Purification Purified by Protein A.
Antigène
Autre désignation Apba1 (APBA1 Antibody Extrait)
Sujet

The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the â^-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11Beta (Mint 2) and X11(Mint 3).

Synonyms: Adapter protein X11 alpha, Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, Apba1, APBA1_HUMAN, Mint 1, Mint-1, Neuron specic X11 protein, Neuron-specic X11 protein, Neuronal Munc18 1 interacting protein 1, Neuronal Munc18-1-interacting protein 1, UROP11, x11, X11alpha.

Pathways Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Images (Fournisseur)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) antibody (ABIN1386516) Paraformaldehyde-fixed, paraffin embedded mouse brain; Antigen retrieval by boiling i...
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