The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimerâ€™s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the â^-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11Beta (Mint 2) and X11(Mint 3).
Synonyms: Adapter protein X11 alpha, Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, Apba1, APBA1_HUMAN, Mint 1, Mint-1, Neuron specic X11 protein, Neuron-specic X11 protein, Neuronal Munc18 1 interacting protein 1, Neuronal Munc18-1-interacting protein 1, UROP11, x11, X11alpha.