ERN1 anticorps (AA 252-260)

N° du produit ABIN1387555

Cet anticorps Lapin Polyclonal détecte spécifiquement ERN1 dans WB, ELISA, FACS, IF (cc), IF (p), ICC, IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Souris, Rat et Porc et a été mentionné dans 6+ publications.

Aperçu rapide pour ERN1 anticorps (AA 252-260) (ABIN1387555)

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Reactivité: Humain, Souris, Rat, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ERN1 anticorps

Épitope: AA 252-260

Réactivité croisée: Humain, Souris, Porc, Rat

Homologie: Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IRE1a

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-ERN1 (ABIN1387555)

Chen, Wang, Chen, Wang, Gui, Dai, Fang, Zhang, Lu: "Influence of resveratrol on endoplasmic reticulum stress and expression of adipokines in adipose tissues/adipocytes induced by high-calorie diet or palmitic acid." dans: Endocrine, Vol. 55, Issue 3, pp. 773-785, (2017) (PubMed).

He, Xu, Gou, Yuan, Liao, Chen, Fan, Xie, Deng, Zhang, Chen, Zhao: "CSFV Infection Up-Regulates the Unfolded Protein Response to Promote Its Replication." dans: Frontiers in microbiology, Vol. 8, pp. 2129, (2017) (PubMed).

Jiang, Yun, Shi, Niu, Gao, Xie, Yu: "Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress." dans: American journal of physiology. Cell physiology, Vol. 310, Issue 9, pp. C755-63, (2016) (PubMed).

Xu, Su, Song, Shi, Fu, Hu, Xia, Song, Song: "Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release." dans: Chemical research in toxicology, Vol. 28, Issue 6, pp. 1326-37, (2015) (PubMed).

Li, Han, Shi: "IRE1?-XBP1 Pathway Is Activated Upon Induction of Single-Prolonged Stress in Rat Neurons of the Medial Prefrontal Cortex." dans: Journal of molecular neuroscience : MN, (2015) (PubMed).

Jiang, Ren, Jiang, Wang, Zhang, Yin, Wang, Qi, Wang, Feng: "Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis." dans: Neuroscience, Vol. 277, pp. 132-8, (2014) (PubMed).

Détails sur ERN1

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Autre désignation: IRE1a

Sujet:

Synonyms: IRE1, IRE1P, IRE1a, hIRE1p, Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, Ire1-alpha, ERN1

Background: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

ID gène: 2081

UniProt: O75460

Pathways: ER-Nucleus Signaling, Unfolded Protein Response