DAB1 anticorps (pTyr198) (Alexa Fluor 350)
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- Antigène Voir toutes DAB1 Anticorps
- DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))
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Épitope
- pTyr198
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Reactivité
- Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DAB1 est conjugé à/à la Alexa Fluor 350
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Rat
- Homologie
- Human,Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Tyr198 [V(p-Y)QY]
- Isotype
- IgG
- Top Product
- Discover our top product DAB1 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))
- Autre désignation
- Dab1 (DAB1 Produits)
- Synonymes
- anticorps AI956902, anticorps C630028C02Rik, anticorps scm, anticorps scr, anticorps scrambler, anticorps yot, anticorps disabled-1, anticorps LOC100232823, anticorps si:dkey-242m13.1, anticorps DAB1, anticorps zgc:136547, anticorps DAB1, reelin adaptor protein, anticorps disabled 1, anticorps disabled homolog 1, anticorps Dab, reelin signal transducer, homolog 1a (Drosophila), anticorps Dab, reelin signal transducer, homolog 1b (Drosophila), anticorps DAB1, anticorps Dab1, anticorps LOC100232823, anticorps dab1a, anticorps dab1b
- Sujet
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Synonyms: Dab1 phospho Y198, Dab1 Tyr198 , Dab 1, Dab1, Dab-1, DAB1_HUMAN, Disabled homolog 1, Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari.
Background: Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl (1). Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants (2). Reelin is a secreted protein thought to play a role in directing migrating neurons (3). Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain (4). Dab2 (also designated DOC-2) is a mitogen-responsive phosphoprotein that binds the SH3 domain of Grb2, and it is thought to be a negative regulator of growth (5).
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