P2RY14 anticorps (AA 125-230) (Biotin)

N° du produit ABIN1394743

Détail du produit anti-P2RY14 anticorps (Biotin)

Antigène: P2RY14 (Purinergic Receptor P2Y, G-Protein Coupled, 14 (P2RY14))

Épitope: AA 125-230

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp P2RY14 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human G-protein coupled receptor 105

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur P2RY14

Antigène: P2RY14 (Purinergic Receptor P2Y, G-Protein Coupled, 14 (P2RY14))

Autre désignation: GPR105 (P2RY14 Produits)

Synonymes: anticorps BPR105, anticorps GPR105, anticorps P2Y14, anticorps A330108O13Rik, anticorps Gpr105, anticorps purinergic receptor P2Y, G-protein coupled, 14, anticorps purinergic receptor P2Y14, anticorps P2RY14, anticorps P2ry14

Sujet:

Synonyms: A330108O13Rik, G protein coupled receptor for UDP-glucose, G protein-coupled receptor 105, G protein-coupled receptor VTR 15-20, G-protein coupled receptor 105, GPR105, KIAA0001, P2RY14, P2Y purinoceptor 14, P2Y14 receptor, P2Y14, P2Y14 receptor, P2Y14_HUMAN, Purinergic receptor P2Y G protein coupled 14, Similar to TYPE-1 Angiotensin II receptor, UDP-glucose receptor, GPCR GPR105.

Background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR105, also designated P2Y14, is widely expressed throughout many brain regions where it localizes to glial cells, and specifically co-localizes with astrocytes. GPR105 is upregulated when a tissue is immunologically challenged with lipopolysaccharide, leading to the theory that GPR105 may play an important role in modulating peripheral and neuroimmune function.