CSTF2 anticorps (AA 61-160) (Biotin)
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- Antigène Voir toutes CSTF2 Anticorps
- CSTF2 (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa (CSTF2))
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Épitope
- AA 61-160
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CSTF2 est conjugé à/à la Biotin
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Homologie
- Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human CSTF2T/CstF-64
- Isotype
- IgG
- Top Product
- Discover our top product CSTF2 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C for 12 months.
- Date de péremption
- 12 months
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- Antigène
- CSTF2 (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa (CSTF2))
- Autre désignation
- CstF-64 (CSTF2 Produits)
- Synonymes
- anticorps CSTF2, anticorps CstF-64, anticorps fb11e07, anticorps zgc:56346, anticorps zgc:77730, anticorps wu:fb11e07, anticorps 64kDa, anticorps C630034J23Rik, anticorps Cstf64, anticorps CSFT64, anticorps cstF-64, anticorps cstf-64, anticorps cleavage stimulation factor subunit 2, anticorps cleavage stimulation factor, 3' pre-RNA, subunit 2, anticorps cleavage stimulation factor, 3' pre-RNA subunit 2, anticorps CSTF2, anticorps cstf2, anticorps Cstf2, anticorps cstf2.L
- Sujet
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Synonyms: CF1 64 kDa subunit, tau variant, Cleavage stimulation factor 64 kDa subunit, tau variant, CSTF 64 kDa subunit, tau variant, KIAA0689, TauCstF64, CSTFT_HUMAN.
Background: Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation.
- ID gène
- 23283
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