FOXO1 anticorps (AA 165-270) (AbBy Fluor® 647)

N° du produit ABIN1402716

Cet anticorps anti-FOXO1 est un anticorps Lapin Polyclonal détectant FOXO1 dans WB, IF (p) et FACS. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Porc, Chien et Poulet.

Aperçu rapide pour FOXO1 anticorps (AA 165-270) (AbBy Fluor® 647) (ABIN1402716)

Antigène: FOXO1 (Forkhead Box O1 (FOXO1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Chien, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXO1 est conjugé à/à la AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)

Détail du produit anti-FOXO1 anticorps (AbBy Fluor® 647)

Épitope: AA 165-270

Réactivité croisée: Poulet, Boeuf (Vache), Chien, Humain, Souris, Porc, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FOXO1A

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FOXO1

Antigène: FOXO1 (Forkhead Box O1 (FOXO1))

Autre désignation: FOXO1A

Sujet:

Synonyms: Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FOXO1, FKHR, FOXO1A

Background: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells.

Poids moléculaire: 72kDa

ID gène: 2308

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling