KLF1/2/4 anticorps (AA 279-303) (Alexa Fluor 350)

N° du produit ABIN1403235

Détail du produit anti-KLF1/2/4 anticorps (Alexa Fluor 350)

Antigène: KLF1/2/4 (Kruppel-Like Factor 1/2/4 (KLF1/2/4))

Épitope: AA 279-303

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KLF1/2/4 est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human KLF1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur KLF1/2/4

Antigène: KLF1/2/4 (Kruppel-Like Factor 1/2/4 (KLF1/2/4))

Abstract: KLF1/2/4 Produits

Sujet:

Synonyms: EKLF, INLU, CDAN4, HBFQTL6, Krueppel-like factor 1, Erythroid krueppel-like transcription factor, KLF1

Background: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).

ID gène: 10661

UniProt: Q13351