Proteoglycan 4 anticorps (AA 1151-1250) (HRP)
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- Antigène Voir toutes Proteoglycan 4 (PRG4) Anticorps
- Proteoglycan 4 (PRG4)
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Épitope
- AA 1151-1250
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Reactivité
- Souris, Rat, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Proteoglycan 4 est conjugé à/à la HRP
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Souris, Lapin, Rat
- Homologie
- Human,Dog,Cow
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Lubricin/SZP
- Isotype
- IgG
- Top Product
- Discover our top product PRG4 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Conseil sur la manipulation
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- Proteoglycan 4 (PRG4)
- Autre désignation
- Lubricin/SZP (PRG4 Produits)
- Synonymes
- anticorps CACP, anticorps HAPO, anticorps JCAP, anticorps MSF, anticorps SZP, anticorps bG174L6.2, anticorps lubricin, anticorps prg4, anticorps si:dkey-97o5.3, anticorps zgc:122988, anticorps PRG4, anticorps DOL54, anticorps proteoglycan 4, anticorps proteoglycan 4b, anticorps proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein), anticorps PRG4, anticorps Prg4, anticorps prg4b
- Sujet
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Synonyms: Superficial zone proteoglycan, articular superficial zone protein, bG174L6.2, CACP, camptodactyly arthropathy coxa vara pericarditis syndrome gene, FLJ32635, HAPO, Jacobs camptodactyly-arthropathy-pericarditis syndrome gene, JCAP, megakaryocyte stimulating factor, MSF, PRG 4, PRG4, proteoglycan 4, Proteoglycan4, Superficial zone proteoglycan, SZP.
Background: Lubricin, also designated proteoglycan-4 or megakaryocyte stimulating factor, is important for boundary lubrication within articulating joints. It is a disulfide-linked homodimer (between Cysteine 1146 and Cysteine 1403) that is essential for protein cleavage. Lubricin inhibits synovial cell adhesion to the cartilage surface, but also prevents the deposition of proteins from synovial fluid onto cartilage. Lubricin is highly expressed in cartilage, liver and synovial tissue. Defects in the gene encoding for lubricin can cause Jakobs syndrome, also designated camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). CACP is an autosomal recessive disorder characterized by joint failure associated with noninflammatory synoviocyte hyperplasia and subinitimal fibrosis of the synovial capsule. Lubricin undergoes different levels of glycosylation and may be detected at varying molecular weights.
- ID gène
- 10216
- UniProt
- Q92954
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