ERN1 anticorps (AA 252-260) (HRP)

N° du produit ABIN1418014

Cet anticorps Lapin Polyclonal détecte spécifiquement ERN1 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Souris, Rat et Porc.

Aperçu rapide pour ERN1 anticorps (AA 252-260) (HRP) (ABIN1418014)

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Reactivité: Humain, Souris, Rat, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERN1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ERN1 anticorps (HRP)

Épitope: AA 252-260

Réactivité croisée: Humain, Souris, Porc, Rat

Homologie: Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IRE1a

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ERN1

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Autre désignation: IRE1a

Sujet:

Synonyms: IRE1, IRE1P, IRE1a, hIRE1p, Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, Ire1-alpha, ERN1

Background: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

ID gène: 2081

UniProt: O75460

Pathways: ER-Nucleus Signaling, Unfolded Protein Response