ATR anticorps

N° du produit ABIN1449281

L’anticorps anti-ATR Monoclonal produit chez le Souris a été validé pour WB. Il convient pour la détection de ATR dans des échantillons provenant de Humain. }

Aperçu rapide pour ATR anticorps (ABIN1449281)

Antigène: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATR est non-conjugé

Application: Western Blotting (WB)

Clone: 4D7

Détail du produit anti-ATR anticorps

Séquence: CPCELEHSIK PLFQHSPGDS SQED

Specificité: This antibody reacts with human ATR.

Purification: Protein A agarose

Immunogène: Carrier protein (CP) conjugated synthetic peptide

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur ATR

Antigène: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Autre désignation: ATR / FRP1

Sujet: ATR (ataxia telangiectasia and Rad-3-related) is one of the most important checkpoint proteins in mammalian cells responding to DNA damage. ATR is a member of the phosphatidylinositol kinase-related protein family that includes ATM (ataxia telangiectasia mutated). These kinases are essential for signaling the presence of DNA damage or replication blocks and activating cell cycle checkpoints. It is reported that checkpoint kinase 1 (CHK1), RAD9, RAD17, Histone H2AX, p53, and BRCA1 are phosphorylated in response to genotoxic stress in an ATR-dependent manner. ATR also phosphorylates ATR-interacting protein (ATRIP) that regulates ATR expression, and is an essential component of the DNA damage checkpoint signaling pathways. In addition, homozygous deletion of ATR in mice causes early embryonic lethality, suggesting that ATR has essential functions during development.Synonyms: Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, Serine/threonine-protein kinase ATR

ID gène: 545

NCBI Accession: NP_001175

UniProt: Q13535

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus