GRB2 anticorps (N-Term)

N° du produit ABIN1449302

L’anticorps anti-GRB2 Monoclonal produit chez le Souris a été validé pour WB. Il convient pour la détection de GRB2 dans des échantillons provenant de Humain, Souris et Rat. }

Aperçu rapide pour GRB2 anticorps (N-Term) (ABIN1449302)

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GRB2 est non-conjugé

Application: Western Blotting (WB)

Clone: 3F2

Détail du produit anti-GRB2 anticorps

Épitope: N-Term

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Ammonium sulfate precipitation and affinity chromatography on protein A

Immunogène: Recombinant Ash/Grb-2

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 100 μL of distilled water.

Buffer: PBS, 1 mg/mL Sodium azide, 10 mg/mL sucrose

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.

Détails sur GRB2

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Autre désignation: GRB2 / ASH

Sujet: Grb2 (Growth factor receptor bound protein 2) also known as Ash, is a 25-28 kDa molecule composed of central Src homology (SH2) domain and SH3 domains. Grb2 associates with tyrosine phosphorylated proteins such as EGFR, PDGFR, IRS-1, Shc and Gab1 via its Sh2 domain. The SH3 domain of Grb2 binds to Sos, which stimulates the GTP binding activity of Ras, cause activation of MAP kinase and other signaling pathways. Grb2 is an adaptor protein, which does not have enzymatic activity itself. Grb2 express ubiquitously and has two isoforms.Synonyms: Growth factor receptor-bound protein 2

ID gène: 2885

NCBI Accession: NP_002077

UniProt: P62993

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation