GRB2 anticorps (N-Term)
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- Antigène Voir toutes GRB2 Anticorps
- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp GRB2 est non-conjugé
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Application
- Western Blotting (WB)
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse, Rat
- Purification
- Ammonium sulfate precipitation and affinity chromatography on protein A
- Immunogène
- Recombinant Ash/Grb-2
- Clone
- 3F2
- Isotype
- IgG1
- Top Product
- Discover our top product GRB2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Reconstitution
- Restore with 100 μL of distilled water.
- Buffer
- PBS, 1 mg/mL Sodium azide, 10 mg/mL sucrose
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
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- Antigène
- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
- Autre désignation
- GRB2 / ASH (GRB2 Produits)
- Synonymes
- anticorps GRB2, anticorps grb2, anticorps AA408164, anticorps Ash, anticorps ASH, anticorps EGFRBP-GRB2, anticorps Grb3-3, anticorps MST084, anticorps MSTP084, anticorps NCKAP2, anticorps wu:fb18e12, anticorps wu:fb34e06, anticorps zgc:73077, anticorps growth factor receptor bound protein 2, anticorps growth factor receptor-bound protein 2, anticorps growth factor receptor-bound protein 2b, anticorps GRB2, anticorps grb2, anticorps Grb2, anticorps grb2b
- Sujet
- Grb2 (Growth factor receptor bound protein 2) also known as Ash, is a 25-28 kDa molecule composed of central Src homology (SH2) domain and SH3 domains. Grb2 associates with tyrosine phosphorylated proteins such as EGFR, PDGFR, IRS-1, Shc and Gab1 via its Sh2 domain. The SH3 domain of Grb2 binds to Sos, which stimulates the GTP binding activity of Ras, cause activation of MAP kinase and other signaling pathways. Grb2 is an adaptor protein, which does not have enzymatic activity itself. Grb2 express ubiquitously and has two isoforms.Synonyms: Growth factor receptor-bound protein 2
- ID gène
- 2885
- NCBI Accession
- NP_002077
- UniProt
- P62993
- Pathways
- Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
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