anticorps HACS1, anticorps NASH1, anticorps SASH2, anticorps SH3D6B, anticorps SLy2, anticorps 4930571B16Rik, anticorps 930571B16Rik, anticorps Hacs1, anticorps Nash, anticorps samsn1, anticorps wu:fa92h05, anticorps wu:fq83f12, anticorps SAMSN1, anticorps zgc:103427, anticorps SAM domain, SH3 domain and nuclear localization signals 1, anticorps SAM domain, SH3 domain and nuclear localization signals, 1, anticorps SAM domain, SH3 domain and nuclear localisation signals 1a, anticorps SAM domain, SH3 domain and nuclear localisation signals 1b, anticorps SAMSN1, anticorps Samsn1, anticorps samsn1a, anticorps samsn1b
Sujet
SAMSN (HACS1) is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains. It encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and malignancies including myeloid leukemia, lymphoma, and myeloma. SAMSN has restricted expression in human tissues. It has been shown to be up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. SAMSN is an immunoinhibitory adaptor that might be a useful target for immune suppression therapy.Synonyms: HACS1, Hematopoietic adaptor containing SH3 and SAM domains 1, SAM domain SH3 domain and nuclear localization signals protein 1, SAM domain-containing protein SAMSN-1, SAMSN-1, SH3-SAM adaptor protein