RAPGEF3 anticorps (N-Term)

N° du produit ABIN1450085

Détail du produit anti-RAPGEF3 anticorps

Antigène: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAPGEF3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid synthetic peptide near the amino terminus of human EPAC1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur RAPGEF3

Antigène: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Autre désignation: EPAC1 (RAPGEF3 Produits)

Synonymes: anticorps RAPGEF3, anticorps epac, anticorps si:dkey-27m20.2, anticorps CAMP-GEFI, anticorps EPAC, anticorps EPAC1, anticorps HSU79275, anticorps bcm910, anticorps 2310016P22Rik, anticorps 9330170P05Rik, anticorps Epac, anticorps Epac1, anticorps Rap guanine nucleotide exchange factor 3, anticorps Rap guanine nucleotide exchange factor 3 S homeolog, anticorps Rap guanine nucleotide exchange factor (GEF) 3, anticorps RAPGEF3, anticorps rapgef3.S, anticorps rapgef3, anticorps Rapgef3

Sujet: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.Synonyms: RAPGEF3, Rap guanine nuclear exchange factor 3, bcm910, cAMPGEF-I

ID gène: 10411

NCBI Accession: NP_659099

Pathways: cAMP Metabolic Process