RAB5 anticorps (AA 150-200)

N° du produit ABIN1574080

Détail du produit anti-RAB5 anticorps

Antigène: RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

Épitope: AA 150-200

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAB5 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Rabbit Anti-Rab5 Polyclonal Antibody detects endogenous levels of human, mouse and rat Rab5 protein.

Purification: Immunoaffinity chromatography

Immunogène: KLH-coupled synthetic peptide from within AA 150-200 of human Rab5 protein .

Isotype: IgG

Information d'application

Indications d'application: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.

ELISA: 0.05-0.2 µg/mL
Western blot: 0.5-1 µg/mL
Other applications: user-optimized

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C/-20 °C

Stockage commentaire: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Détails sur RAB5

Antigène: RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

Autre désignation: Rab5 (RAB5A Produits)

Synonymes: anticorps RAB5, anticorps 2410015H04Rik, anticorps AI663973, anticorps AU021172, anticorps nnyRab5a, anticorps DDBDRAFT_0168594, anticorps DDBDRAFT_0229401, anticorps DDB_0168594, anticorps DDB_0229401, anticorps rab5, anticorps RAB5A, anticorps Rab5a, anticorps rab5al, anticorps zgc:56644, anticorps fj38g08, anticorps hm:zehn1144, anticorps rab5a, anticorps wu:fj38g08, anticorps RAB5A, member RAS oncogene family, anticorps rab5A protein, anticorps Rab5a, GTPase, anticorps predicted protein, anticorps Rab GTPase, anticorps RAB5A, member RAS oncogene family L homeolog, anticorps RAB5A, member RAS oncogene family, b, anticorps RAB5A, member RAS oncogene family, a, anticorps RAB5A, anticorps Rab5a, anticorps rab5A, anticorps rab5a, anticorps rab5a.L, anticorps rab5ab, anticorps rab5aa

Sujet: Small GTPase Rab5 is a member of Rab family which binds to GTP and exhibits GTPase activity. Rab5 protein is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. Rabaptin-5 serves as an effector of Rab5 and mediates the tuberin association with Rab5. RNTRE protein whose activity is regulated by EGFR activates Rab5 GTPase. RNTRE acts on Rab5 and inhibits EGFR's internalization. The ALS2 protein specifically binds to Rab5 and functions as a guanine nucleotide exchange factor (GEF) for Rab5. As a key regulator of endocytosis, signal transduction, and mitogenesis, Rab5 protein is also a signaling GTPase that elucidates the major molecular elements of its downstream pathway.Rabbit Anti-Rab5 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from within residues 150-200 of human Rab5 protein (Swiss Prot: P20339).

Pathways: Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity