CDK5 anticorps (C-Term)

N° du produit ABIN1574122

Détail du produit anti-CDK5 anticorps

Antigène: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK5 est non-conjugé

Application: Western Blotting (WB)

Specificité: Rabbit Anti-CDK5 Polyclonal Antibody detects endogenous levels of human, mouse, and rat CDK5.Positive Control: Hela, HEK293, mouse brain and rat brain.

Réactivité croisée (Details): Rabbit Anti-CDK5 Polyclonal Antibody detects endogenous levels of human, mouse, and rat CDK5.Positive Control: Hela, HEK293, mouse brain and rat brain.

Purification: Immunoaffinity chromatography

Immunogène: KLH-coupled synthetic peptide from C-terminal of human CDK5 .

Isotype: IgG2b

Information d'application

Indications d'application: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Western blot: 0.5-1 µg/mLOther Applications: user-optimized

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C/-20 °C

Stockage commentaire: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Détails sur CDK5

Antigène: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Autre désignation: CDK5 (CDK5 Produits)

Synonymes: anticorps PSSALRE, anticorps AW048668, anticorps Crk6, anticorps CDK5, anticorps CG8203, anticorps DmCdk5, anticorps Dmel\\CG8203, anticorps cdk5, anticorps zgc:101604, anticorps cyclin dependent kinase 5, anticorps cyclin-dependent kinase 5, anticorps Cyclin-dependent kinase 5, anticorps cyclin-dependent kinase 5 L homeolog, anticorps Cyclin-dependent-like kinase 5, anticorps CDK5, anticorps Cdk5, anticorps cdk5, anticorps cdk5.L, anticorps cdk-5

Sujet: Cyclin dependent kinase 5 (CDK5), a member of the cyclin-dependent kinase family, plays crucial roles in neuronal differentiation, migration, axon outgrowth and synaptogenesis. CDK5 is a proline-directed serine/threonine (Ser/Thr) kinase that phosphorylates a diverse range of substrates, such as histone H1, TAU, MAP2 and NF-H and NF-M. The activity of CDK5 depends on the combination of neuron specific activator proteins, p35 or p39 or their truncated forms, p25 and p29. CDK5 phosphorylates the transcription factor myocyte enhancer factor 2 in mediation of neurotoxic effects. The conversion of p35 to p25 by calpain gives rise to prolonged activation of CDK5. Deregulated CDK5 activity has been implicated in neurodegenerative diseases, including Alzheimer-disease, Parkinsons disease and amyotrophic lateral sclerosis.Rabbit Anti-CDK5 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human CDK5 (Swiss Prot: Q00535).

Pathways: Cycle Cellulaire, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis