EEA1 anticorps (N-Term)

N° du produit ABIN1574158

Détail du produit anti-EEA1 anticorps

Antigène: EEA1 (Early Endosome Antigen 1 (EEA1))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EEA1 est non-conjugé

Application: Veuillez nous consulter SVP

Specificité: Rabbit Anti-EEA1 Polyclonal Antibody detects endogenous levels of human, mouse and rat EEA1 protein.

Réactivité croisée: Souris, Rat (Rattus)

Attributs du produit: Rabbit Anti-EEA1 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human EEA1 (Swiss Prot: Q15075).

Purification: Immunoaffinity chromatography

Immunogène: KLH-coupled synthetic peptide from N-terminal of human EEA1

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/mL.

Concentration: 0.5 mg/mL

Buffer: Lyophilized with PBS, pH 7.4, containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below.

Références pour anticorps anti-EEA1 (ABIN1574158)

Tian, Zhu, Hu, Wang, Huang, Xiao: "Dynamics of exosome internalization and trafficking." dans: Journal of cellular physiology, Vol. 228, Issue 7, pp. 1487-95, (2013) (PubMed).

Hazeki, Kametani, Murakami, Uehara, Ishikawa, Nigorikawa, Takasuga, Sasaki, Seya, Matsumoto, Hazeki: "Phosphoinositide 3-kinase? controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages." dans: PLoS ONE, Vol. 6, Issue 10, pp. e26836, (2011) (PubMed).

Détails sur EEA1

Antigène: EEA1 (Early Endosome Antigen 1 (EEA1))

Autre désignation: EEA1 (EEA1 Produits)

Synonymes: anticorps MST105, anticorps MSTP105, anticorps ZFYVE2, anticorps im:7151048, anticorps si:ch211-276p10.2, anticorps A430109M19Rik, anticorps B230358H09Rik, anticorps early endosome antigen 1, anticorps early endosome antigen 1 S homeolog, anticorps EEA1, anticorps eea1, anticorps Eea1, anticorps eea1.S

Sujet: Early endosomal antigen 1 (EEA1) is an early endosomal marker which is essential for fusion between early endocytic vesicles. It interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion. EEA1 protein contains an N-terminal zinc finger motif and a cys-rich C-terminal metal-binding finger. A FYVE domain located at the carboxy terminus of EEA1 binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes.

Poids moléculaire: Predicted Band Size: 162 KD
Observed Band Size: 162 KD

UniProt: Q15075

Pathways: Toll-Like Receptors Cascades