CENPW anticorps (N-Term)

N° du produit ABIN1587944

Détail du produit anti-CENPW anticorps

Antigène: CENPW (Centromere Protein W (CENPW))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CENPW est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: At least three isoforms of CENPW are known to exist, this antibody will detect all three isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogène: CENPW antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CENPW.

Isotype: IgG

Information d'application

Indications d'application: CENPW antibody can be used for detection of CENPW by Western blot at 0.5 - 1 μg/mL.

Commentaires:

(NT) Centromere protein W

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: 4 °C

Stockage commentaire: CENPW antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Date de péremption: 12 months

Détails sur CENPW

Antigène: CENPW (Centromere Protein W (CENPW))

Autre désignation: CENPW (CENPW Produits)

Synonymes: anticorps C6orf173, anticorps CUG2, anticorps 2610036L11Rik, anticorps Cug2, anticorps CENP-W, anticorps centromere protein W, anticorps CENPW, anticorps Cenpw

Sujet: CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.

ID gène: 387103

NCBI Accession: NP_001012525