GPR17 anticorps (AA 2-100) (Alexa Fluor 350)

N° du produit ABIN1693026

Détail du produit anti-GPR17 anticorps (Alexa Fluor 350)

Antigène: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Épitope: AA 2-100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR17 est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human G protein coupled receptor 17

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GPR17

Antigène: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Autre désignation: GPR17 (GPR17 Produits)

Synonymes: anticorps GPR17, anticorps AI853548, anticorps G protein-coupled receptor 17, anticorps GPR17, anticorps Gpr17

Sujet:

Synonyms: DKFZp686M18273, G protein coupled receptor 17, G-protein coupled receptor 17, GPR 17, Gpr17, GPR17_HUMAN, P2Y like receptor, P2Y-like receptor, Probable P2Y purinoceptor GPR 17, Probable P2Y purinoceptor GPR17, R12, UDP/CysLT receptor, Uracil nucleotide/cysteinyl leukotriene receptor, GPCR GPR17.

Background: G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events.

ID gène: 2840

UniProt: Q13304