BCL6B anticorps (AA 141-440) (Alexa Fluor 647)

N° du produit ABIN1698057

Détail du produit anti-BCL6B anticorps (Alexa Fluor 647)

Antigène: BCL6B (B-Cell CLL/lymphoma 6, Member B (BCL6B))

Épitope: AA 141-440

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCL6B est conjugé à/à la Alexa Fluor 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human BCL6B

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur BCL6B

Antigène: BCL6B (B-Cell CLL/lymphoma 6, Member B (BCL6B))

Autre désignation: BCL6B (BCL6B Produits)

Synonymes: anticorps BAZF, anticorps ZBTB28, anticorps ZNF62, anticorps Bazf, anticorps RGD1563179, anticorps B-cell CLL/lymphoma 6B, anticorps B cell CLL/lymphoma 6, member B, anticorps B-cell CLL/lymphoma 6, member B, anticorps BCL6B, anticorps Bcl6b, anticorps bcl6b

Sujet:

Synonyms: B cell CLL/lymphoma 6, member B zinc finger protein, B-cell CLL/lymphoma 6, member B zinc finger protein, BAZF, Bcl6 associated zinc finger protein, Bcl6-associated zinc finger protein, ZBTB28, Zinc finger protein 62, ZNF62.

Background: Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NF_B expression, thereby inhibiting NF_B-mediated cellular functions. Bcl-6b (B-cell CLL/lymphoma 6, member B), also known as ZNF62, BAZF or ZBTB28, is a 480 amino acid nuclear protein that contains one BTB (POZ) domain and five C2H2-type zinc fingers. Expressed ubiquitously with highest expression in placenta and heart, Bcl-6b associates with Bcl-6 and functions as a sequence-specific transcriptional repressor that is thought to be necessary for early B-cell development. The gene encoding Bcl-6b maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes.

Pathways: BCR Signaling