ERBB4 anticorps (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian)) (pTyr1258) (HRP)

Details for Product anti-ERBB4 Antibody No. ABIN1712442, Fournisseur: Connectez-vous pour afficher
Antigène
  • erbb4
  • si:ch211-227n20.1
  • Her4
  • c-erbB-4
  • HER4
  • p180erbB4
  • erb-b2 receptor tyrosine kinase 4
  • erb-b2 receptor tyrosine kinase 4a
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
  • erb-b2 receptor tyrosine kinase 4 L homeolog
  • receptor tyrosine-protein kinase ErbB-4
  • ERBB4
  • erbb4a
  • erbb4
  • erbb4.L
  • Tsp_13582
  • Erbb4
Épitope
pTyr1258
54
36
36
32
21
19
18
17
15
14
13
9
7
5
5
5
4
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
377
173
139
10
7
5
4
4
4
3
3
3
2
2
2
1
1
1
Hôte
Lapin
290
92
1
Clonalité
Polyclonal
Conjugué
Cet anticorp ERBB4 est conjugé à/à la HRP
20
18
16
15
14
10
9
9
7
7
7
5
5
5
5
5
5
4
4
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
210
145
126
92
68
58
28
21
15
5
5
3
2
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène KLH conjugated synthetic phosphopeptide derived from human HER4 around the phosphorylation site of Tyr1258 [PD(p-Y)LQ ]
Isotype IgG
Purification Purified by Protein A.
Autre désignation Her4 (ERBB4 Antibody Extrait)
Sujet

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

Synonyms: ErbB 4 phospho Y1258, p-ErbB 4 phospho Y1258, ErbB4, HER 4, HER4, Avian erythroblastic leukemia viral oncogene homolog 4, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4, MGC138404, P180erbB4, Receptor protein tyrosine kinase erbB 4 precursor, Receptor tyrosine protein kinase erbB 4,Tyrosine kinase type cell surface receptor HER4, v erb a avian erythroblastic leukemia viral oncogene homolog like 4, v erb a erythroblastic leukemia viral oncogene homolog 4, Verba avian erythroblastic leukemia viral oncogene homolog like 4, Verba erythroblastic leukemia viral oncogene homolog 4, VERBB2.

ID gène 2066
Pathways Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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