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TOM1L1 anticorps (AA 1-100)

TOM1L1 Reactivité: Humain WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1713582
  • Antigène Voir toutes TOM1L1 Anticorps
    TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))
    Épitope
    • 14
    • 11
    • 9
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-100
    Reactivité
    • 52
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 44
    • 6
    • 1
    Lapin
    Clonalité
    • 48
    • 4
    Polyclonal
    Conjugué
    • 24
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TOM1L1 est non-conjugé
    Application
    • 43
    • 22
    • 12
    • 12
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human TOM1L1
    Isotype
    IgG
    Top Product
    Discover our top product TOM1L1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))
    Autre désignation
    TOM1L1 (TOM1L1 Produits)
    Synonymes
    anticorps MGC52738, anticorps srcasm, anticorps TOM1L1, anticorps OK/KNS-CL.3, anticorps SRCASM, anticorps RGD1562626, anticorps Srcasm, anticorps 2310045L10Rik, anticorps C80573, anticorps target of myb1 like 1 membrane trafficking protein L homeolog, anticorps target of myb1 like 1 membrane trafficking protein, anticorps target of myb1-like 1 (chicken), anticorps tom1l1.L, anticorps TOM1L1, anticorps tom1l1, anticorps Tom1l1
    Sujet

    Synonyms: OK/KNS CL.3, Src activating and signaling molecule, Src activating and signaling molecule protein, Src-activating and signaling molecule protein, SRCASM, Target of Myb like protein 1, Target of Myb-like protein 1, Target of myb1 chicken homolog like 1, Target of myb1 chicken like 1, Target of myb1 like 1, TM1L1_HUMAN, TOM1 L1, TOM1 like protein 1, TOM1-like protein 1, TOM1L1, TOM1L1 protein.

    Background: Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin.

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