AKT2 anticorps

N° du produit ABIN1724720

Il existe 2+ publications pour ce produit. L’anticorps anti-AKT2 Monoclonal Souris est utilisé pour la détection de AKT2 dans des échantillons de Humain, Rat et Singe. Il a été validé pour WB, ELISA, IHC et ICC.

Aperçu rapide pour AKT2 anticorps (ABIN1724720)

Antigène: AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))

Reactivité: Humain, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AKT2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: 1B6

Détail du produit anti-AKT2 anticorps

Fonction: AKT2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human AKT2 expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-AKT2 (ABIN1724720)

Gosmanov, Umpierrez, Karabell, Cuervo, Thomason: "Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes." dans: American journal of physiology. Endocrinology and metabolism, Vol. 287, Issue 1, pp. E8-E15, (2004) (PubMed).

Xu, Sakon, Nagano, Hiraoka, Yamamoto, Hayashi, Dono, Nakamori, Umeshita, Ito, Matsuura, Monden: "Akt2 expression correlates with prognosis of human hepatocellular carcinoma." dans: Oncology reports, Vol. 11, Issue 1, pp. 25-32, (2003) (PubMed).

Détails sur AKT2

Antigène: AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))

Autre désignation: AKT2

Sujet: Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53 kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.

Poids moléculaire: 60 kDa

UniProt: P31751

Pathways: Signalisation PI3K-Akt, Signalisation RTK, AMPK Signaling, Signalisation TLR, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Hepatitis C, VEGF Signaling