RCHY1 anticorps

N° du produit ABIN1724723

Détail du produit anti-RCHY1 anticorps

Antigène: RCHY1 (Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RCHY1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purification: purified

Immunogène: Purified recombinant fragment of human Pirh2 expressed in E. coli.

Clone: 1H10

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-RCHY1 (ABIN1724723)

Duan, Gao, Wu, Zhang, Otterson, Villalona-Calero: "Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells." dans: Experimental cell research, Vol. 312, Issue 17, pp. 3370-8, (2006) (PubMed).

Duan, Gao, Druhan, Zhu, Morrison, Otterson, Villalona-Calero: "Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer." dans: Journal of the National Cancer Institute, Vol. 96, Issue 22, pp. 1718-21, (2004) (PubMed).

Détails sur RCHY1

Antigène: RCHY1 (Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))

Autre désignation: Pirh2 (RCHY1 Produits)

Synonymes: anticorps ARNIP, anticorps CHIMP, anticorps PIRH2, anticorps PRO1996, anticorps RNF199, anticorps ZNF363, anticorps Pirh2, anticorps Zfp363, anticorps Znf363, anticorps wu:fb37e07, anticorps zgc:101128, anticorps RCHY1, anticorps arnip, anticorps chimp, anticorps pirh2, anticorps harnip, anticorps rnf199, anticorps znf363, anticorps pro1996, anticorps ring finger and CHY zinc finger domain containing 1, anticorps ring finger and CHY zinc finger domain containing 1 L homeolog, anticorps RCHY1, anticorps Rchy1, anticorps rchy1, anticorps rchy1.L

Sujet:

Description: Pirh 2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function.

Aliases: ARNIP, CHIMP, RNF199, RCHY1

Poids moléculaire: 30 kDa, 60 kDa (homodimer)

ID gène: 25898

HGNC: 25898