Integrin Alpha2b anticorps (AA 45-149)

N° du produit ABIN1724822

L’anticorps Souris Monoclonal anti-Integrin Alpha2b a été validé pour FACS, IHC et ELISA. Il convient pour détecter Integrin Alpha2b dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour Integrin Alpha2b anticorps (AA 45-149) (ABIN1724822)

Antigène: Integrin Alpha2b (CD41)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin Alpha2b est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA

Clone: 2E10C9

Détail du produit anti-Integrin Alpha2b anticorps

Épitope: AA 45-149

Fonction: ITGA2B Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Integrin Alpha2b (ABIN1724822)

Park, Chung, Lee, Park, Kim, Kim: "Novel and recurrent mutations of ITGA2B and ITGB3 genes in Korean patients with Glanzmann thrombasthenia." dans: Pediatric blood & cancer, Vol. 59, Issue 2, pp. 335-8, (2012) (PubMed).

Nurden, Fiore, Nurden, Pillois: "Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models." dans: Blood, Vol. 118, Issue 23, pp. 5996-6005, (2011) (PubMed).

Détails sur Integrin Alpha2b

Antigène: Integrin Alpha2b (CD41)

Autre désignation: ITGA2B

Sujet: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Poids moléculaire: 113.4 kDa

ID gène: 3674

UniProt: P08514

Pathways: Integrin Complex