Macrophage Mannose Receptor 1 anticorps

N° du produit ABIN181886

Détail du produit anti-Macrophage Mannose Receptor 1 anticorps

Antigène: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Macrophage Mannose Receptor 1 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Specificité: This antibody recognises the Mannose Receptor, a 175 kDa type 1 membrane protein that is also known as CD206. Clone MR5D3 has been reported to be non-inhibitory for the binding of the mannose receptor to carbohydrate ligands.

Purification: Affinity Chromatography on Protein G

Immunogène: Chimaeric CRD4-7-Fc protein. Remarks: Spleen cells from immunised Fischer rats were fused with cells of the Y3 myeloma cell line.

Clone: MR5D3

Isotype: IgG2a

Information d'application

Indications d'application: Western Blot. Immunoprecipitation. Immunohistochemistry on frozen sections. Flow Cytometry: 1/10 - 1/20, Use 10 μL of the suggested working dilution to label 10^6 cell in 100 μL, CD206 is expressed weakly at the cell surface. Staining may be increased following membrane permeabilisation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Macrophage Mannose Receptor 1

Antigène: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Autre désignation: CD206 / MRC1 (MRC1 Produits)

Synonymes: anticorps CD206, anticorps CLEC13D, anticorps CLEC13DL, anticorps MMR, anticorps MRC1L1, anticorps bA541I19.1, anticorps AW259686, anticorps MR, anticorps mrc1, anticorps MGC86525, anticorps MRC1, anticorps MRC1L-A, anticorps mannose receptor C-type 1, anticorps mannose receptor, C type 1, anticorps mannose receptor C-type 1 L homeolog, anticorps mediator of replication checkpoint 1, anticorps MRC1, anticorps Mrc1, anticorps mrc1.L, anticorps mrc1

Sujet: CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. CD206 is a phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature Dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.Synonyms: C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, CLEC13D, CLEC13DL, MRC1L1, Macrophage mannose receptor, Macrophage mannose receptor 1-like protein 1

ID gène: 17533

NCBI Accession: NP_032651

UniProt: Q61830