DAXX anticorps
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- Antigène Voir toutes DAXX Anticorps
- DAXX (Death-Domain Associated Protein (DAXX))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp DAXX est non-conjugé
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)
- Purification
- Purified by Protein G affinity chromatography
- Immunogène
- Purified recombinant fragment of human DAXX expressed in E. Coli.
- Isotype
- IgG1
- Top Product
- Discover our top product DAXX Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 50 % glycerol and 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
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- Antigène
- DAXX (Death-Domain Associated Protein (DAXX))
- Autre désignation
- DAXX (DAXX Produits)
- Synonymes
- anticorps BING2, anticorps DAP6, anticorps EAP1, anticorps LOC100226911, anticorps daxx, anticorps si:dz179b20.7, anticorps wu:fd15c03, anticorps death domain associated protein, anticorps Fas death domain-associated protein, anticorps 28S ribosomal protein S29, mitochondrial, anticorps death-domain associated protein, anticorps death-associated protein 6 L homeolog, anticorps DAXX, anticorps Daxx, anticorps LOC100226911, anticorps daxx.L, anticorps daxx
- Sujet
- Daxx is a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF beta R2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF beta R2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described.
- Poids moléculaire
- 81 kDa
- ID gène
- 1616
- UniProt
- Q9UER7
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
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