DYNLL1 anticorps (Cytoplasmic)

N° du produit ABIN187402

Détail du produit anti-DYNLL1 anticorps

Antigène: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Épitope: Cytoplasmic

Reactivité: Humain, Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp DYNLL1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificité: Recognizes human and mouse DLC1. Does not cross-react with DLC2. Species Reactivity: Mouse and human. Others not tested.

Immunogène: Recombinant mouse DLC1 [LC8, PIN].

Clone: 10D6

Isotype: IgM

Information d'application

Indications d'application: Flow Cytometry. Western blot: use at least a 1:1,000 dilution. The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL.

Buffer: 100 µg affinity purified antibody in PBS containing 0.02% sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur DYNLL1

Antigène: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Autre désignation: DYNLL1 (DYNLL1 Produits)

Synonymes: anticorps DLC1, anticorps DLC8, anticorps DNCL1, anticorps DNCLC1, anticorps LC8, anticorps LC8a, anticorps PIN, anticorps hdlc1, anticorps dynll2, anticorps wu:fd56c09, anticorps zgc:73406, anticorps Dlc8, anticorps Dnclc1, anticorps Pin, anticorps 8kDLC, anticorps lc8, anticorps dlc1, anticorps dlc8, anticorps lc8a, anticorps dncl1, anticorps dnclc1, anticorps dynll1a, anticorps MGC68763, anticorps CDLC2, anticorps dynll1, anticorps dynll1b, anticorps pin, anticorps MGC89636, anticorps dynein light chain LC8-type 1, anticorps dynein, light chain, LC8-type 1, anticorps dynein light chain LC8-type 1 S homeolog, anticorps dynein light chain LC8-type 1 L homeolog, anticorps Dynein light chain 1, cytoplasmic, anticorps DYNLL1, anticorps dynll1, anticorps Dynll1, anticorps dynll1.S, anticorps dynll1.L, anticorps dlc-1

Sujet: The 10 kDa dynein light chain 1 (DLC1, LC8), also known as neuronal nitric oxide synthase inhibitory protein or PIN (protein inhibitor of nNOS), is a component of cytoplasmic dynein, which is involved in the minus end-directed movement of organelles along microtubules. It is a highly conserved protein that is associated with the microtubular dynein motor complex by its binding to dynein intermediate chain (DIC). This allows DLC1 to act as a cargo protein, hooking many different proteins to the dynein motor complex. Binding of the BH3-only protein, Bim, to DLC1 also controls its pro-apoptotic activity. In healthy cells, most Bim molecules are sequestered from Bcl-2 and its homologs by DLC1 mediated binding to the dynein motor complex. Certain apoptotic signals, such as cytokine withdrawal or deregulated calcium flux, induces the release of Bim and DLC1 from the dynein motor complex. This allows Bim and DLC1 to translocate and bind to Bcl-2 and its homologs, thus neutralizing their anti-apoptotic activity.

Pathways: M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity