Caspase 9 anticorps (N-Term)

N° du produit ABIN187521

Cet anticorps anti-Caspase 9 Monoclonal Souris (Clone LAP6-96) (ABIN187521) détecte spécifiquement Caspase 9 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Caspase 9 anticorps (N-Term) (ABIN187521)

Antigène: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 9 est non-conjugé

Application: Western Blotting (WB)

Clone: LAP6-96

Détail du produit anti-Caspase 9 anticorps

Épitope: N-Term

Stérilité: 0.2 μm filtered

Immunogène: Synthetic peptide corresponding to amino acids 2 to 22 of human caspase-9.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Mouse monoclonal antibody against human Caspase-9 (cysteine-requiring aspartate protease-9). Available in 100 µl vials at a concentration of 1 mg/ml (100 µg) in PBS with 0.08% sodium azide. Purified by 0.2 µm sterile filtration.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur Caspase 9

Antigène: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Autre désignation: Caspase-9

Sujet: Caspases are key effectors of programmed cell death. They are synthesized as inactive pro-enzymes, which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker, which may be involved in the regulation of the different caspases. Caspase-9 is a member of the CED-3 family and is very similar to caspase-3. Pro-caspase-9 can be activated by either caspase-3 or granzyme B, although they cleave the pro-enzyme to different size subunits. Cleavage by granzyme B produces an active enzyme, which is capable of cleaving PARP. Also, the ability of caspase-3 to activate caspase-9 seems to suggest that caspase-9 is further downstream of caspase-3 and may be involved in later changes in cells observed undergoing apoptosis.

Pathways: Signalisation MAPK, Signalisation RTK, Apoptose, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity