CHM anticorps (AA 292-320)

N° du produit ABIN1881197

Détail du produit anti-CHM anticorps

Antigène: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Épitope: AA 292-320

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHM est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CHM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human CHM.

Clone: RB42411

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CHM (ABIN1881197)

Renner, Fiebig, Cropp, Weber, Kellner: "Progression of retinal pigment epithelial alterations during long-term follow-up in female carriers of choroideremia and report of a novel CHM mutation." dans: Archives of ophthalmology, Vol. 127, Issue 7, pp. 907-12, (2009) (PubMed).

Détails sur CHM

Antigène: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Autre désignation: CHM (CHM Produits)

Synonymes: anticorps CHM, anticorps REP1, anticorps DXS540, anticorps GGTA, anticorps HSD-32, anticorps REP-1, anticorps TCD, anticorps DKFZp459K2154, anticorps tcd, anticorps ggta, anticorps rep-1, anticorps dxs540, anticorps hsd-32, anticorps MGC68578, anticorps Rep-1, anticorps chm, anticorps chm-a, anticorps chm-b, anticorps chml, anticorps CHM, Rab escort protein 1, anticorps choroideremia (Rab escort protein 1), anticorps choroideremia (Rab escort protein 1) L homeolog, anticorps choroidermia (RAB escort protein 1), anticorps choroideremia (Rab escort protein 1) S homeolog, anticorps CHM, anticorps chm, anticorps chm.L, anticorps Chm, anticorps chm.S

Sujet: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia, also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 73476

NCBI Accession: NP_000381, NP_001138886

UniProt: P24386

Pathways: Sensory Perception of Sound