EGFR anticorps (pSer768)

N° du produit ABIN1881286

Cet anticorps Lapin Polyclonal détecte spécifiquement EGFR dans WB et DB. Il présente une réactivité envers Humain et a été mentionné dans 5+ publications.

Aperçu rapide pour EGFR anticorps (pSer768) (ABIN1881286)

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGFR est non-conjugé

Application: Western Blotting (WB), Dot Blot (DB)

Clone: RB11271

Détail du produit anti-EGFR anticorps

Épitope: pSer768

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This EGFR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S768 of human EGFR.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-EGFR (ABIN1881286)

Aifa, Aydin, Nordvall, Lundström, Svensson, Hermanson: "A basic peptide within the juxtamembrane region is required for EGF receptor dimerization." dans: Experimental cell research, Vol. 302, Issue 1, pp. 108-14, (2004) (PubMed).

Adams, McKern, Ward: "Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor." dans: Growth factors (Chur, Switzerland), Vol. 22, Issue 2, pp. 89-95, (2004) (PubMed).

Ichinose, Murata, Yanagida, Sako: "EGF signalling amplification induced by dynamic clustering of EGFR." dans: Biochemical and biophysical research communications, Vol. 324, Issue 3, pp. 1143-9, (2004) (PubMed).

Kuribayashi, Kataoka, Kurabayashi, Miura: "Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells." dans: Endocrinology, Vol. 145, Issue 11, pp. 4976-84, (2004) (PubMed).

Kapoor, Zhan, Johnson, ORourke: "Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells." dans: Molecular and cellular biology, Vol. 24, Issue 2, pp. 823-36, (2003) (PubMed).

Détails sur EGFR

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Autre désignation: EGFR

Sujet: Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. EGFR is a receptor for EGF, but also for other members of the EGF family, including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. It is involved in the control of cell growth and differentiation

Poids moléculaire: 134277

NCBI Accession: NP_005219, NP_958439, NP_958440, NP_958441

UniProt: P00533

Pathways: Signalisation NF-kappaB, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins