KCNAB1 anticorps (N-Term)

N° du produit ABIN1881473

Détail du produit anti-KCNAB1 anticorps

Antigène: KCNAB1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 1 (KCNAB1))

Épitope: AA 15-44, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNAB1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This KCNAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human KCNAB1.

Clone: RB40526

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-KCNAB1 (ABIN1881473)

Decher, Gonzalez, Streit, Sachse, Renigunta, Soom, Heinemann, Daut, Sanguinetti: "Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2." dans: The EMBO journal, Vol. 27, Issue 23, pp. 3164-74, (2008) (PubMed).

Cavalleri, Weale, Shianna, Singh, Lynch, Grinton, Szoeke, Murphy, Kinirons, ORourke, Ge, Depondt, Claeys, Pandolfo, Gumbs, Walley, McNamara, Mulley, Linney, Sheffield, Radtke, Tate, Chissoe et al.: "Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study...." dans: Lancet neurology, Vol. 6, Issue 11, pp. 970-80, (2007) (PubMed).

Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." dans: Genomics, Vol. 89, Issue 3, pp. 307-15, (2007) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." dans: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Détails sur KCNAB1

Antigène: KCNAB1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 1 (KCNAB1))

Autre désignation: KCNAB1 (KCNAB1 Produits)

Synonymes: anticorps KCNAB1, anticorps zgc:113627, anticorps AKR6A3, anticorps KCNA1B, anticorps KV-BETA-1, anticorps Kvb1.3, anticorps hKvBeta3, anticorps hKvb3, anticorps Kvbeta1.1, anticorps KVBETA1, anticorps Kv-beta-1, anticorps Akr8a8, anticorps mKv(beta)1, anticorps KvBeta3, anticorps potassium voltage-gated channel subfamily A member regulatory beta subunit 1, anticorps potassium voltage-gated channel, shaker-related subfamily, beta member 1 a, anticorps potassium voltage-gated channel, shaker-related subfamily, beta member 1, anticorps KCNAB1, anticorps kcnab1a, anticorps Kcnab1

Sujet: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.

Poids moléculaire: 46563

NCBI Accession: NP_003462, NP_751891, NP_751892

UniProt: Q14722