PARP1 anticorps (pThr373)

N° du produit ABIN1881631

Cet anticorps Lapin Polyclonal détecte spécifiquement PARP1 dans DB. Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 4+ publications.

Aperçu rapide pour PARP1 anticorps (pThr373) (ABIN1881631)

Antigène: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP1 est non-conjugé

Application: Dot Blot (DB)

Clone: RB40141

Détail du produit anti-PARP1 anticorps

Épitope: pThr373

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T373 of human PARP1.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PARP1 (ABIN1881631)

Dong, Bey, Li, Kabbani, Yan, Xie, Hsieh, Gao, Boothman: "Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation." dans: Cancer research, Vol. 70, Issue 20, pp. 8088-96, (2010) (PubMed).

Krishnakumar, Kraus: "PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway." dans: Molecular cell, Vol. 39, Issue 5, pp. 736-49, (2010) (PubMed).

Majewski, Thurston, Ramalingam, Kiela, Ghishan: "Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts." dans: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34828-38, (2010) (PubMed).

Kim, Kang, Lee, Lee, Lee, Choi, Lee, Cho, Jin, Jheon, Son, Lee, Jung, Cha, Kim, Kang, Kam, Jung, Jheon, Park: "Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer." dans: Cancer science, Vol. 101, Issue 11, pp. 2436-42, (2010) (PubMed).

Détails sur PARP1

Antigène: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Autre désignation: PARP1

Sujet: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Poids moléculaire: 113084

NCBI Accession: NP_001609

UniProt: P09874

Pathways: Apoptose, Caspase Cascade in Apoptosis, Réparation de l'ADN, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location