PPP2R1A anticorps (C-Term)

N° du produit ABIN1881682

Détail du produit anti-PPP2R1A anticorps

Antigène: PPP2R1A (Protein Phosphatase 2, Regulatory Subunit A, alpha (PPP2R1A))

Épitope: AA 454-481, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP2R1A est non-conjugé

Application: Western Blotting (WB)

Homologie: B, M, Pig

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PPP2R1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-481 amino acids from the C-terminal region of human PPP2R1A.

Clone: RB41029

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PPP2R1A (ABIN1881682)

Jones, Wang, Shih, Mao, Nakayama, Roden, Glas, Slamon, Diaz, Vogelstein, Kinzler, Velculescu, Papadopoulos: "Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma." dans: Science (New York, N.Y.), Vol. 330, Issue 6001, pp. 228-31, (2010) (PubMed).

Schmitz, Held, Janssens, Hutchins, Hudecz, Ivanova, Goris, Trinkle-Mulcahy, Lamond, Poser, Hyman, Mechtler, Peters, Gerlich: "Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells." dans: Nature cell biology, Vol. 12, Issue 9, pp. 886-93, (2010) (PubMed).

Dupont, Breyer, Bradley, Schuyler, Plummer, Sanders, Page, Smith: "Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk." dans: Cancer, Vol. 116, Issue 1, pp. 8-19, (2010) (PubMed).

Heikkinen, Nummela, Leivonen, Westermarck, Hill, Kähäri, Jaakkola: "Hypoxia-activated Smad3-specific dephosphorylation by PP2A." dans: The Journal of biological chemistry, Vol. 285, Issue 6, pp. 3740-9, (2010) (PubMed).

Wang, Gao, Wang, Flagg, Deng: "A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair." dans: Neoplasia (New York, N.Y.), Vol. 11, Issue 10, pp. 1012-21, (2009) (PubMed).

Détails sur PPP2R1A

Antigène: PPP2R1A (Protein Phosphatase 2, Regulatory Subunit A, alpha (PPP2R1A))

Autre désignation: PPP2R1A (PPP2R1A Produits)

Synonymes: anticorps PP2A-Aalpha, anticorps PP2AAALPHA, anticorps PR65A, anticorps PR65, anticorps pp2a-aalpha, anticorps pp2aaalpha, anticorps ppp2r1a, anticorps pr65a, anticorps wu:fa02h04, anticorps zgc:56296, anticorps 6330556D22Rik, anticorps PP2A, anticorps ppp2r1a-a, anticorps ppp2r1a-b, anticorps protein phosphatase 2 scaffold subunit Aalpha, anticorps protein phosphatase 2 scaffold subunit A alpha, anticorps protein phosphatase 2 regulatory subunit A, alpha L homeolog, anticorps protein phosphatase 2 regulatory subunit A, alpha, anticorps protein phosphatase 2, regulatory subunit A, beta a, anticorps serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, anticorps protein phosphatase 2, regulatory subunit A, alpha isoform, anticorps protein phosphatase 2, regulatory subunit A, alpha, anticorps protein phosphatase 2 regulatory subunit A, alpha S homeolog, anticorps PPP2R1A, anticorps Ppp2r1a, anticorps ppp2r1a.L, anticorps ppp2r1a, anticorps ppp2r1ba, anticorps LOC583227, anticorps ppp2r1a.S

Sujet: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq].

Poids moléculaire: 65309

NCBI Accession: NP_055040

UniProt: P30153

Pathways: Signalisation PI3K-Akt, Mitotic G1-G1/S Phases, M Phase, Hepatitis C, Toll-Like Receptors Cascades